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BCRL Home » BCRL Collaboration’s Network

BCRL Collaboration’s Network

The BCRL  has 12 different sites of collaboration:

  1. Collaborative studies between the BCRL at FCCC and the Institurte for Experimental Medicine, Buenos Aires,  Argentina supported by the International Union Against Cancer. The study was based on the finding that acquired and constitutive antiprogestin resistance correlates with a diminished expression of Progesterone Receptor A (PR-A), suggesting that PR-A may be regulated by epigenetic mechanisms. We were able to demonstrate that the promoters or PR-A are methylated in mammary carcinomas with constitutive antiprogestin resistance but not in those with acquired resistance. The publication below reflects the finding:
    • Wargon V, Fernandez SV, Goin M, Giulianelli S, Russo J, Lanari CLM. Hypermethylation of the progesterone receptor-A in constitutive anti-progestin resistant mouse. Breast Cancer Res Treat. 2011 126(2):319-32, 2011.


  2. Collaborative studies between the BCRL at FCCC and the Universidade Federal de Sao Paulo (UNIFESP). This work was supported by a grant from CAPES (Coordenação de Aperfeicoamento de Perssoal de Nivel Superior) Brazil And the Susan G. Komen Promise Grant KG 26222 on Breast cancer prevention granted to Prof. J. Russo These studies were  aimed to  determine the role of short amino acid peptides of hCG in  the prevention of breast cancer. The publication below reflects the finding.
    • Noronha, S.M.R. and Correa-Noronha, S.A.A.; Russo, I.H.; Lopez de Cicco, R.;  Santucci-Pereira, J.; Russo, J. hCG and a 15aa  peptide of the hormone  induce down-regulation of CXCR1 gene  in normal breast epithelial cells. Hormone Molecular Biology and Clinical Investigation 6:(3)241-245, 2011.


  3. Collaborative studies between the BCRL at FCCC and the University of Alabama, Birminghan Alabama with Dr Coral Lamartiniere and supported by theU01 ES016003. The aims of these studies were geared to determine the genomic and proteomic biomarkers of biological exposure as Indicators of environmental stress. The publications below reflects our findings:
    • Lamartiniere, C. A., Jenkins, S., Betancourt, A.M. Wang, J., and Russo, J. Exposure to the Endocrine Disruptor Bisphenol A Alters Susceptibility for Mammary Cancer. Horm Mol Biol Clin Invest5(2):46-52, 2011.
    • Moral R, Santucci-Pereira J, Wang R, Russo IH, Lamartiniere CA, Russo J. In utero exposure to butyl benzyl phthalate induces modifications in the morphology and the gene expression profile of the mammary gland: an experimental study in rats. Environmental Health. 10(1):5-12, 2011. 
    • Russo, I.H. and Russo, J. In search of the optimal experimental model in: Environment and breast cancer(J Russo Ed.) Springer, NY, pp 43-54, 2011.
    • Lopez de Cico, R., Santucci-Pereira, J., Moral R., Peri, S., Slifker, M., Russo,I.H., Russo, P.A.,Wang, R., and Russo, J. Endocrine  disruptors affetct the genomic profile of the rat mammary gland at different developmental stages. In: Environment and breast cancer (J Russo Ed.) Springer, NY, pp 69101, 2011.
    • Fernandez, s.V., Huang, Y., Snider, K.E., Zhow, Y., Pogash, T.J. and Russo J.  Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure.  International Journal of Oncology 41: 369-377, 2012.
    • Angela M Betancourt; Jun Wang; Sarah Jenkins; Jim Mobley; Jose Russo; Coral A Lamartiniere.Altered carcinogenesis and proteome in mammary glands of rats after prepubertal exposures to the hormonally active chemicals bisphenol A and genistein. J. Nutr. 142, (2012).
    • Betancourt A, Mobley JA, Wang J, Jenkins S, Chen DQ, Kojima K, Russo J, Lamartiniere CA. Alterations in the Rat Serum Proteome Induced by Prepubertal Exposure to Bisphenol A and Genistein. Journal of Proteome Research, 13(3):1502-14, 2014.
    • López de Cicco R, Santucci Pereira J , Russo PA, Medvedovic M, Pinney SM, Biro FM Lamartiniere CA, and Russo J. Altered gene expression in blood of girls with high urine concentrations of Bisphenol-A, Diethyl hexyl phthalate and Butyl benzyl phthalate. Cancer Epidemiology, Biomarkers & Prevention (In Press) (2015)


  4. Collaborative studies between the BCRL at FCCC and the Penn State University  with Dr Andrea Manni supported by the Susan G. Komen Promise Grant KG37663. The aims of these studies were geared to study the role of combination of low-dose anti-estrogens with omega-3 fatty acids for prevention of hormone-independent breast cancer. The publications below reflect our findings:
    • Carina Signori, Karam El-Bayoumy, Jose Russo, Henry Thompson, John Richie ,Terryl Hartman, Andrea Manni Chemoprevention of Breast Cancer by Fish Oil in Preclinical Models:  Trials and Tribulations. Cancer Research 71:6091-6, 2011.
    • Lucas Tadeu Bidinotto, Ricardo López de Cicco, Jose Russo; Omega-3 fatty acids: a potential booster for tamoxifen therapy? Expert Review of Anticancer Therapy, 11:1151-1153, 2011.
    • Bidinotto, L. T., R. L. de Cicco, J. E. Vanegas, J. Santucci-Pereira, J. P. Vanden Heuvel, S. Washington, C. Aliaga, H. Xu, I. H. Russo, A. Manni, K. El-Bayoumy and J. Russo. "Fish oil alters tamoxifen-modulated expression of mRNAs that encode genes related to differentiation, proliferation, metastasis, and immune response in rat mammary tumors. Nutr Cancer 64 (7): 991-999, 2012.
    • Zhai, Y., Santucci-Pereira, Julia., Lopez de Cicco, RicardoRusso, Irma H. and Russo. J. n vitro–in vivo model of epithelial mesenchymal transition in triple egative breast cancer. Drug Discovery Today: Disease Mechanisms 9 (1-2)35-40, 2012.
    • Jin-Qiang Chen, Ph.D.; Jose Russo. Dysregulation of Glucose Transport, Glycolysis, TCA Cycle and Glutaminolysis by Oncogenes and Tumor Suppressors in Cancer Cells. BBA - Reviews on Cancer 2013.
    • Russo,J. Significance of Rodent Mammary Tumors for Human Risk Assessment Toxicologic Pathology Online publication  May,2014.The paper publication will take place in March 2015.
    • Pogash, T. J.,  El-Bayoumy, K.,,Amin, S.,  Gowda, K., López de Cicco, R., Barton, M., Su, Y., Russo, I.H., Himmelberger. J.A., Slifker, M., Manni, A., and  Russo, J. Oxidized derivative of docosahexanoic acid preferentially inhibit cell proliferation in triple negative over luminal breast cancer cells. In vitro Cellular and Developmental Biology-Animal, Published online, November 2014.

  5. Collaborative studies between the BCRL at FCCC, the New York Univeristy, and the University of Umea in Sweden. This work was supported by AVON-3263201. The aims of these studies were geared to the characterization and validation of genomic expression signature of pregnancy. The publications below reflect our findings:
    • Ilana BL, Zeleniuch-Jacquotte A, Russo J, Russo IH, Bordas P, Ahman J, Afanasyeva Y, Johansson R, Lenner P, Li X, Lopez de Cicco R, Peri S, Ross E, Russo PA, Santucci-Pereira J, Sheriff FS, Slifker M, Hallmans G, Toniolo P, Arslan AA. Characterization of a Genomic Signature of Pregnancy in the Breast. Cancer Prevention  Research 4: 1457-1464, 2011.
    •  Russo,  Irma H., Russo, Jose.  Pregnancy-Induced Changes in Breast Cancer Risk. A Review. Mammary Gland Biology And Neoplasia, 16:221-233, 2011.
    •  Jose Russo,  Julia Santucci-Pereira, Ricardo López de Cicco, Fathima Sheriff, Patricia A. Russo, Suraj Peri, Michael Slifker, Eric Ross, Maria Luiza S. Mello, Benedicto C. Vidal, Ilana Belitskaya- Lévy, Alan Arslan, Anne Zeleniuch-Jacquotte, Pal Bordas, Per Lenner, Janet Ahman, Yelena Afanasyeva, Goran Hallmans, Paolo Toniolo, Irma H. Russo. Pregnancy-induced chromatin remodeling in the breast of postmenopausal women. Int. J. Cancer:131, 1059–1070, 2012.Suraj Peri, Ricardo López de Cicco, Julia Santucci-Pereira, Michael Slifker, Eric A Ross, Irma H Russo, Patricia A Russo, Alan A Arslan, Ilana Belitskaya-Lévy, Anne Zeleniuch-Jacquotte, Pal Bordas, Per Lenner, Janet Åhman, Yelena Afanasyeva, Robert Johansson, Fathima Sheriff, Göran Hallmans, Paolo Toniolo and Jose Russo. Defining the genomic signature of the parous breast. BMC Medical Genomics. 5:46-56, 2012.
    •  Russo, J. and Russo, Irma H., Molecular basis of pregnancy-induced breast cancer prevention. Hormone Molecular Biology and Clinical Investigation 9:3-10, 2012.
    • Santucci-Pereira J., George, C., Armiss, D., Russo, I.H., Vanegas, J.E., Sheriff, F., Lopez de Cicco, R., Su, Y., Russo, P.A., Bidinotto, L.T., and Russo, J.  Mimicking Pregnancy as a Strategy for Breast Cancer Prevention. Breast Cancer Management 2(4)283-294, 2013.
    • Russo, J and Russo, IH.  Hormonal control of Breast development In: Endocrinology(Sixth edition) Edited by L. J. DeGroot and J.L. Jameson. W.B. Elsevier, Chapter 123, 2014.
    • Russo J, Santucci-Pereira J, and Russo IH. The genomic signature of breast cancer prevention. Genes, 5(1):65-83, 2014. PMC3978512.
    • Santucci-Pereira J, George C, Armiss D, Russo IH, Vanegas JE, Sheriff F, de Cicco RL, Su Y, Russo PA, Bidinotto LT, Russo J. Mimicking pregnancy as a strategy for breast cancer prevention. Breast cancer management, 2 (4):283-94, 2013. PMC3984583.
    • Russo, J., Santucci-Pereira, J. and Barton, MMolecular Pathways involved in Pregancy-Induced Prevention Against Breast Cancer.Frontiers in Endocrinology, section Cellular Endocrinology.(In press) 2015.

  6. Collaborative studies between the BCRL at FCCC and the Department of Surgery of the Dokuz Eylul University Hospital at Inciraiti, Izmir, Turkey. This collaboration was possible by a grant from the Fulbright Scholarship Program. In this project we studied the role of the Glucose transporter 3 in breast cancer. The publication below reflects our findings:
    •  Kocdor MA, Kocdor H, Pereira JS, Vanegas JE, Russo IH, Russo J.  Progressive increase of glucose transporter-3 (GLUT-3) expression in estrogen-induced breast carcinogenesis. Clin Transl Oncol. 15:55-64, 2013.
     
  7. Collaborative studies between the BCRL at FCCC and the University of Texas Health Science CTR in San Antonio, Texas with Dr Tim Huang and supported by AVON-3263201. The aim of our collaboration is for determining the epigenetic profile of the breast of nulliparous and parous women and its role in the genomic signature of prevention in breast cancer. This collaboration is still ongoing and we are actively analyzing the data generated. Only one publication was generated thus far from this collaboration:
    • Santucci-Pereira J, George C, Armiss D, Russo IH, Vanegas JE, Sheriff F, de Cicco RL, Su Y, Russo PA, Bidinotto LT, Russo J. Mimicking pregnancy as a strategy for breast cancer prevention. Breast cancer management, 2(4):283-94, 2013. PMC3984583.

  8. Collaborative studies between the BCRL at FCCC and the Lawrence Berkeley Laboratory, San Francisco California with Dr Kohwi-Shigematsu and supported by R37 CA039681. The collaborative work is aiming to understand the gene regulation by chromatin organization of human breast cancer cells and has been based on the two publications in 2008 and listed below:
    • Hye-Jung Han, H.J., Russo, J., Kohwi, Y., Kohwi-Shigematsu, T. SATB1 reprograms gene expression to promote breast cancer metastasis. Nature 452:187. 2008.
    • Russo J, Han HJ, Kohwi Y, Kohwi-Shigematsu T. New advances in breast cancer metastasis. Women Health (Lond Engl), 4:547-9, 2008.

  9. Collaborative studies between the BCRL at FCCC and Department of Health Sciences University of Genoa, Italy,  with Dr  Silvio De Flora, MD. These studies are supported by the NCI Prevent grant to Dr Margie Clapper. The objective of this collaboration is to assess the role of tobacco exposure in the development of the mammary gland and its risk in cancer initiation. This collaboration was established only 10 months ago is still ongoing and no publication has been generated thus far.

  10. Collaborative studies between the BCRL at FCCC and University of Ghent in Belgium with Prof. Hernan Depypere and Dr. Jaak Janssens. This collaboration is aiming to perform a clinical trial in young women at high risk of breast cancer using the r-hCG as a preventive measure. The support for these studies is originated from the European Cancer Prevention Organization. This collaboration was established in November 2014 and is still in process of obtaining the adequate IRB approval. We have presented an LOI to Avon foundation for supporting the molecular studies of the samples collected in this trial.

  11. Collaborative studies between the BCRL at FCCC andthe Medical School of University National of Cuyo, in Mendoza, Argentina with Dr Ernesto Gago and Dr. Laura Vargas Roig. This collaboration is aiming to perform a clinical trial in young women at high risk of breast cancer using the r-hCG as a preventive measure. The support for these studies is originated from the Medical school of University of Cuyo that is the Alma Matter of Prof. J. Russo. This collaboration was established in September of 2014 and is still in process of obtaining the adequate IRB approval. We have presented a LOI to Avon foundation for supporting the molecular studies of the samples collected in this trial.

  12. Collaborative arrangements with Drexel University in Philadelphia for the Co-Op program of internship in breast cancer research. On February 2012 we have established an agreement with Drexel University to have, through their Co-Op program, interns that rotate for six months Ad Honorem working 20 hours a week for their training in breast cancer research. Their unique background in engineering and biology provide a significant intellectual force that has been easily integrated in our research endeavor. Thus far more than 50 interns had rotated in this program. Their input in our research has been established in the following publications:
    • Julia Santucci-Pereira, Steven G. Doll, Ryan R. Smalley, Colleen O’ Malley, Irma H. Russo, Russo, J. Methological Approaches for the Understanding the Epigenetic Landscape of the of the Human Breast and its Implications in Cancer and Prevention.In: Methodological Approaches to Breast Cancer Research.(Edited by Jose Russo and I. H. Russo), Springer, New York, Chapter 10 pages 253-284, 2014.
    • Russo, J., Thomas Pogash, Janine Gomes, Justin Newton, Ricardo Lopez de Cicco, Yanrong Su and Irma H. Russo. In vitro techniques for studying the normal breast and the use of cell lines in breast cancer research.In: Methodological Approaches to Breast Cancer Research.(Edited by Jose Russo and I. H. Russo), Springer, New York, Chapter 5, pages 119-150, 2014.